Neurogenesis Epigenetic DNA Demethylation and Adult Neuronal Activity Induced Gadd 45 b Promotes
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منابع مشابه
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis.
The mammalian brain exhibits diverse types of neural plasticity, including activity-dependent neurogenesis in the adult hippocampus. How transient activation of mature neurons leads to long-lasting modulation of adult neurogenesis is unknown. Here we identify Gadd45b as a neural activity-induced immediate early gene in mature hippocampal neurons. Mice with Gadd45b deletion exhibit specific defi...
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تاریخ انتشار 2009